Clinicopathological Characteristics of Colorectal Cancer in the Anatomical Pathology Laboratory of Dr. M. Djamil Padang 2017-2020

Authors

  • Muhammad Farhan Hasan Andalas University
  • Noza Hilbertina Andalas University
  • Deddy Saputra Andalas University

DOI:

https://doi.org/10.62951/ijhsb.v1i4.102

Keywords:

Colorectal Cancer, Clinical Features, Histopathology Features

Abstract

Colorectal cancer is a malignant epithelial tumor originating from colorectal mucosa. Clinicopathology factors including age, gender, location, histopathological type, differentiation, depth of invasion, lymph node metastasis, and lymphovascular invasion are known affect the prognosis. This study aims to determine the clinicopathological characteristics of colorectal cancer at Anatomical Pathology Laboratory RSUP. Dr. M. Djamil Padang in 2017-2020 This study was descriptive observational with total sampling technique from medical records. Samples included all colorectal cancer patients in 2017-2020 who were fulfilled inclusion criteria, with total 251 samples. The results showed that the most patiens were female (52.2%), the age group were > 50 years (66.1%), mostly located in the rectosigmoid (71.7%). Most of the histopathological types were adenocarcinoma (79.7%), with low grade differentiation (88.8%). More than a half of tumor invasion was at T3 (58.2%). Mainly metastatic status to lymph nodes was Nx (54.2%) and lymphovascular invasion were positive in 60% samples that included the lymphovascular invasion examination. The conclusion of this study is most of colorectal cancer in Anatomical Pathology Laboratory RSUP. Dr. M. Djamil Padang in 2017-2020 are in advanced stage, Early detection needs to be done so that colorectal cancer can be diagnosed at an early stage.

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References

American Cancer Society. (2017). Colorectal cancer facts & figures 2017-2019 (pp. 1–40). Centers for Disease Control and Prevention.

Bromley, D. W. (1989). Economic interests and institutions: The conceptual foundations of public policy (p. 29). Basil Blackwell.

Budianto, H. (2019). Ekologi sungai di Kalimantan dan dampaknya terhadap ekonomi pasar terapung (pp. 8–21). Banjarmasin: Penerbit Kalimantan Press.

Gunasekaran, V., Ekawati, N. P., & Sumadi, I. W. J. (2019). Karakteristik klinikopatologi karsinoma kolorektal di RSUP Sanglah, Bali, Indonesia tahun 2013-2017. Intisari Sains Medis, 10(3), 552–556.

Hamdi, M., Zahari, A., & Asri, A. (2015). Profil karsinoma kolorektal di laboratorium patologi anatomi Fakultas Kedokteran Universitas Andalas periode Januari 2009 sampai Desember 2011. Jurnal Kesehatan Andalas, 4(2), 398–403.

Harahap, A. R. N. (2019). Kejadian kanker kolorektal di RSUD Dr. H. Abdul Moeloek Bandar Lampung. Laporan Penelitian.

Hashimoto, R., Matsuda, T., Hamamoto, H., Yamaoka, H., Nakahori, M., & Chonan, A. (2016). Usefulness of dilated blood vessels in the tumor periphery for assessing the invasion depth of small-sized depressed colorectal cancer. Medicine (Baltimore), 95(25). https://doi.org/10.1097/MD.0000000000003903

Hilbertina, N., Siregar, N. C., Abdullah, M., & Wanandi, S. I. (2020). Determination of cancer associated fibroblast and stromal phenotypes as novel prognostic factors for colorectal carcinomas associated with tumor budding. BMC Cancer, 20(27). https://doi.org/10.1186/s12885-020-07219-7

Iskandar, M. (2021). Perubahan struktur ekonomi lokal di Kalimantan: Pengaruh industrialisasi pesisir. Jurnal Pengembangan Wilayah, 5(1), 33–47.

Kurniawan, T., Zahari, A., & Asri, A. (2017). Hubungan usia dengan kedalaman invasi dan gambaran histopatologi pada penderita karsinoma kolorektal di Bagian Patologi Anatomi Fakultas Kedokteran UNAND pada tahun 2008 sampai 2012. Jurnal Kesehatan Andalas, 6(2), 351–358.

Liana, N., Liana, N., Hilbertina, N., Devianti, L., & Yetti, H. (2022). Hubungan ekspresi vascular endothelial growth factor (VEGF) dengan derajat diferensiasi dan invasi limfovaskular pada adenokarsinoma kolorektal. Jurnal Kedokteran Raflesia, 6(2), 368–375.

Maguire, A., & Sheahan, K. (2014). Controversies in the pathological assessment of colorectal cancer. World Journal of Gastroenterology, 20(29), 9850–9865.

Misdraji, J., & Carr, N. J. P. R. (2019). WHO classification of tumours 5th edition: Digestive system tumours. WHO Classification of Tumours Editorial Board (pp. 141–143).

Naxerova, K., Reiter, J. G., Brachtel, E., Lennerz, J., Van de Wetering, M., Rowan, A., et al. (2017). Origins of lymphatic and distant metastases in human colorectal cancer. Science, 357(6346), 55. https://doi.org/10.1126/science.aan0448

Nomura, M., Takahashi, H., Fujii, M., Miyoshi, N., Haraguchi, N., Hata, T., et al. (2019). Clinical significance of invasion distance relative to prognosis in pathological T3 colorectal cancer. Oncology Letters, 18(5), 5614–5620. https://doi.org/10.3892/ol.2019.10676

Organization WH. (2020). Cancer incidence in Indonesia. WHO Report (pp. 1–2).

Society AC. (2014). Understanding your pathology report: Invasive adenocarcinoma of the colon (pp. 1–2). https://www.cancer.org/treatment/understanding-your-diagnosis/tests/understanding-your-pathology-report/colon-pathology/invasive-adenocarcinoma-of-the-colon.html

Stintzing, S., Tejpar, S., Gibbs, P., Thiebach, L., & Lenz, H. J. (2017). Understanding the role of primary tumour localization in colorectal cancer treatment and outcomes. European Journal of Cancer, 84, 69–76. https://doi.org/10.1016/j.ejca.2017.06.008

Sukarman, A. (2018). Sejarah infrastruktur kemaritiman dan pembangunan ekonomi di Kalimantan. Yogyakarta: Gadjah Mada University Press.

Susanti, L. (2019). Peran aktivitas kemaritiman dalam perekonomian lokal di Kalimantan. Jurnal Maritim Indonesia, 6(1), 102–115.

World Health Organization. (2006). WHO classification of tumours of the colon and rectum (4th ed.).

World Health Organization. (2021). Cancer. https://www.who.int/health-topics/cancer#tab=tab_1

Zhong, J. W., Yang, S. X., Chen, R. P., Zhou, Y. H., Ye, M. S., Miao, L., et al. (2019). Prognostic value of lymphovascular invasion in patients with stage III colorectal cancer: A retrospective study. Medical Science Monitor, 25, 6043. https://doi.org/10.12659/MSM.916940

Published

2024-10-11

How to Cite

Muhammad Farhan Hasan, Noza Hilbertina, & Deddy Saputra. (2024). Clinicopathological Characteristics of Colorectal Cancer in the Anatomical Pathology Laboratory of Dr. M. Djamil Padang 2017-2020. International Journal of Health and Social Behavior, 1(4), 22–32. https://doi.org/10.62951/ijhsb.v1i4.102